Unraveling framework of the ancestral Mediator complex in human diseases.

Claudio Napoli, Marcella Sessa, Teresa Infante, Amelia Casamassimi

Department of General Pathology and Excellence Research Centre on Cardiovascular Diseases, 1st School of Medicine, Second University of Naples, Complesso S. Andrea delle Dame Via Costantinopoli 16, 80138 Naples, Italy. claudio.napoli@unina2.it

Biochimie 2012 Mar

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Mediator (MED) is a fundamental component of the RNA polymerase II-mediated transcription machinery. This multiprotein complex plays a pivotal role in the regulation of eukaryotic mRNA synthesis. The yeast Mediator complex consists of 26 different subunits. Recent studies indicate additional pathogenic roles for Mediator, for example during transcription elongation and non-coding RNA production. Mediator subunits have been emerging also to have pathophysiological roles suggesting MED-dependent therapeutic targets involving in several diseases, such as cancer, cardiovascular disease (CVD), metabolic and neurological disorders. Copyright © 2011 Elsevier Masson SAS. All rights reserved.

Citation

Claudio Napoli, Marcella Sessa, Teresa Infante, Amelia Casamassimi. Unraveling framework of the ancestral Mediator complex in human diseases. Biochimie. 2012 Mar;94(3):579-87