Making of viral replication organelles by remodeling interior membranes.

Positive-stranded RNA (+RNA) viruses exploit host cell machinery by subverting host proteins and membranes and altering cellular pathways during infection. To achieve robust replication, some +RNA viruses, such as poliovirus (PV), build special intracellular compartments, called viral replication organelles. A recent work from the Altan-Bonnett laboratory [1] gave new insights into the formation of poliovirus replication organelles, which are unique subcellular structures containing many individual replication complexes as a result of dynamic cellular membrane remodeling.

Citation

Zsuzsanna Sasvari, Peter D Nagy. Making of viral replication organelles by remodeling interior membranes. Viruses. 2010 Nov;2(11):2436-42

PMID: 21994625

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