Reactive oxygen species and 3,4-dihydroxyphenylacetaldehyde in pathogenesis of Parkinson disease].

Iwona Rybakowska, Grzegorz Szreder, Krystian Kaletha, Małgorzata Barwina, Wojciech Waldman, Jacek Sein Anand

Zakład Biochemii i Fizjologii Klinicznej, Gdańskiego Uniwersytetu Medycznego. iwonar@gumed.edu.pl

Przegla̧d lekarski 2011

filter terms:

Reactive oxygen species, which plays a role in pathogenesis of many neurodegenerative diseases, seems to be important also in pathogenesis of the Parkinson's disease. Experiments performed recently, revealed in the cerebrum of patients suffering from this disease (induced by the oxidative stress) elevated levels of 3,4-dihydroxyphenylacetaldehyde (DOPAL)--a strong endogenous neurotoxin to dopamine neurons.

Citation

Iwona Rybakowska, Grzegorz Szreder, Krystian Kaletha, Małgorzata Barwina, Wojciech Waldman, Jacek Sein Anand. Reactive oxygen species and 3,4-dihydroxyphenylacetaldehyde in pathogenesis of Parkinson disease]. Przegla̧d lekarski. 2011;68(8):486-7