In vitro anti-inflammatory effects of naturally-occurring compounds from two Lauraceae plants.

Ericsson D Coy-Barrera, Luis E Cuca-Suarez

Laboratorio de Investigación en Productos Naturales Vegetales, Departamento de Química, Facultad de Ciencias, Universidad Nacional de Colombia, Bogotá DC, Colombia.

Anais da Academia Brasileira de Ciências 2011 Dec

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The in vitro anti-inflammatory effects of seven known lignans and one dihydrochalcone isolated from the leaves of two Lauraceae species (Pleurothyrium cinereum and Ocotea macrophylla), were evaluated through the inhibition of COX-1, COX-2, 5-LOX and the aggregation of rabbit platelets induced by PAF, AA and ADP. (+)-de-4"-O-methylmagnolin 4 was found to be a potent COX-2/5-LOX dual inhibitor and PAF-antagonist (COX-2 IC(50) 2.27 µM; 5-LOX IC(50) 5.05 µM; PAF IC(50) 2.51 µM). However, all compounds exhibited an activity at different levels, indicating good anti-inflammatory properties to be considered in further structural optimization studies.

Citation

Ericsson D Coy-Barrera, Luis E Cuca-Suarez. In vitro anti-inflammatory effects of naturally-occurring compounds from two Lauraceae plants. Anais da Academia Brasileira de Ciências. 2011 Dec;83(4):1397-402