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The aim of the study was to investigate the neurophysiologic bases of impairments of motor and some cognitive functions in apathic depression using neurophysiologic and psychophysiologic methods together with clinical assessment of patient's conditions in the dynamics of treatment. Latencies of main components of auditory cognitive evoked potentials (EP) as well as latencies of simple sensorimotor reaction and of two-alternative choice reaction to auditory stimuli have been analyzed. The significant decrease of mean values of the P3 component of auditory cognitive EP in comparison with baseline (before beginning of treatment) level has been noted in patients at the stage of pronounced clinical improvement while latencies of N1, P2 and N2 components have not changed significantly. The mean values of latencies of both simple sensorimotor reaction and of two-alternative choice reaction have been decreased as well. The peculiarities of correlations between clinical indices of depression severity and values of latencies of components of cognitive EP in left and right hemispheric leads in patients with apathic depression indicate the relationship of depression severity with impairment of functional state of the left hemisphere and with activation of the right hemisphere that is in good concordance with contemporary views on the dominant role of the right brain hemisphere in the pathogenesis of depression.


A F Iznak, E V Iznak, S A Sorokin. Dynamics and relationships of parameters of cognitive evoked potentials and sensorimotor reactions in the treatment of apathic depression]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova / Ministerstvo zdravookhraneniia i meditsinskoĭ promyshlennosti Rossiĭskoĭ Federatsii, Vserossiĭskoe obshchestvo nevrologov [i] Vserossiĭskoe obshchestvo psikhiatrov. 2011;111(9):52-7

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PMID: 22027671

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