Stable disruption of ethanol production by deletion of the genes encoding alcohol dehydrogenase isozymes in Saccharomyces cerevisiae.

Yoshihiro Ida, Chikara Furusawa, Takashi Hirasawa, Hiroshi Shimizu

Department of Bioinformatic Engineering, Graduate School of Information Science and Technology, Osaka University, 1-5 Yamadaoka, Suita, Osaka 565-0871, Japan.

Journal of bioscience and bioengineering 2012 Feb

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We analyzed the effects of the deletions of genes encoding alcohol dehydrogenase (ADH) isozymes of Saccharomyces cerevisiae. The decrease in ethanol production by ADH1 deletion alone could be partially compensated by the upregulation of other isozyme genes, while the deletion of all known ADH isozyme genes stably disrupted ethanol production. Copyright Â© 2011 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.

Citation

Yoshihiro Ida, Chikara Furusawa, Takashi Hirasawa, Hiroshi Shimizu. Stable disruption of ethanol production by deletion of the genes encoding alcohol dehydrogenase isozymes in Saccharomyces cerevisiae. Journal of bioscience and bioengineering. 2012 Feb;113(2):192-5