Butamben derivatives enhance BMP-2-stimulated commitment of C2C12 cells into osteoblasts with induction of voltage-gated potassium channel expression.

Hye Joo Kim, Mikyung Park, Young-Min Han, Byoung-Mog Kwon, Seong Hwan Kim

Laboratory of Chemical Genomics, Pharmacology Research Center, Korea Research Institute of Chemical Technology, PO Box 107, Yuseong-gu, Daejeon 305-600, Republic of Korea.

Bioorganic & medicinal chemistry letters 2011 Dec 15

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As the primary step for 'drug repositioning', we evaluated the effect of 2000 drugs and drug candidates on the commitment of bi-potential mesenchymal precursor C2C12 cells into osteoblasts in the presence of bone morphogenetic protein (BMP)-2 and found that butamben enhanced BMP-2-stimulated induction of alkaline phosphatase, a biomarker of osteoblastogenesis. Investigating the underlying mechanism of its anabolic actions, we found anabolic action of its derivative (compound 4) relies on BMP-2 signaling and mRNA induction of BMPs and voltage-gated potassium channels. Copyright © 2011 Elsevier Ltd. All rights reserved.

Citation

Hye Joo Kim, Mikyung Park, Young-Min Han, Byoung-Mog Kwon, Seong Hwan Kim. Butamben derivatives enhance BMP-2-stimulated commitment of C2C12 cells into osteoblasts with induction of voltage-gated potassium channel expression. Bioorganic & medicinal chemistry letters. 2011 Dec 15;21(24):7363-6