How to connect an IgE-driven response with CTL activity?

Barbara Platzer, Eleonora Dehlink, Shannon J Turley, Edda Fiebiger

Division of Gastroenterology and Nutrition, Children's Hospital Boston, 300 Longwood Ave, Enders 630, Boston, MA 02115, USA.

Cancer immunology, immunotherapy : CII 2012 Sep

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One of the goals of cell-based immune therapy in cancer is the induction of tumor-specific cytotoxic T-lymphocyte (CTL) responses. To achieve this objective, the ability of dendritic cells (DC) to cross-present tumor antigens can be exploited. One of the most efficient pathways for the induction of CTLs by cross-presentation is mediated by immunoglobulins of the IgG class, which are used by DCs to sample antigen in the form of immune complexes via Fc-gamma receptors. Could DCs use an IgE-mediated cross-presentation mechanism in a comparable manner to induce CTLs? We here discuss the potential of two human IgE Fc receptors, FcεRI and FcεRII, to serve as antigen uptake receptors for IgE-mediated cross-presentation. We conclude that the existence of an IgE-mediated cross-presentation pathway would provide a direct link between IgE-driven immune responses and CTL activity.

Citation

Barbara Platzer, Eleonora Dehlink, Shannon J Turley, Edda Fiebiger. How to connect an IgE-driven response with CTL activity? Cancer immunology, immunotherapy : CII. 2012 Sep;61(9):1521-5