Salicylamide and salicylglycine oxidovanadium complexes with insulin-mimetic properties.

Jessica Nilsson, Albert A Shteinman, Eva Degerman, Eva A Enyedy, Tamás Kiss, Ulrich Behrens, Dieter Rehder, Ebbe Nordlander

Chemical Physics, Center for Chemistry and Chemical Engineering, Lund University, Lund, Sweden.

Journal of inorganic biochemistry 2011 Dec

filter terms:

Reaction of N-(2-hydroxybenzyl)-N-(2-picolyl) glycine (H(2)papy) with VOSO(4) in water gives the oxidovanadium(V) oxido-bridged dimer [{(papy)(VO)}(2) μ-O)] (1). Similarly, reaction of N-(2-hydroxybenzyl) glycine (H(2)glysal) with VOSO(4) gives [(glysal)VO(H(2)O)] (2) and reaction of salicylamide (Hsalam) with VOSO(4) in methanol gives [(salam)(2)VO] (3). The crystal structure of the oxido-bridged complex 1 is reported. The insulin-mimetic activity of all three complexes was evaluated with respect to their ability to phosphorylate protein kinase B (PKB). The speciations of complexes 1 and 2 were studied over the pH range 2-10. Complex 1 shows greater stability over the whole pH range but only 2 and 3 exhibit an insulin-mimetic effect. Copyright © 2011 Elsevier Inc. All rights reserved.

Citation

Jessica Nilsson, Albert A Shteinman, Eva Degerman, Eva A Enyedy, Tamás Kiss, Ulrich Behrens, Dieter Rehder, Ebbe Nordlander. Salicylamide and salicylglycine oxidovanadium complexes with insulin-mimetic properties. Journal of inorganic biochemistry. 2011 Dec;105(12):1795-800