In situ mechanical analysis of cardiomyocytes at nano scales.

Yuansheng Liu, Jiantao Feng, Liang Shi, Ruibin Niu, Quanmei Sun, Hao Liu, Jing Li, Jihong Guo, Jihong Zhu, Dong Han

Emergency Department, Peking University People's Hospital, Beijing 100044, People's Republic of China.

Nanoscale 2012 Jan 7

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Nanomechanical behaviors of single living cardiomyocytes are quantitatively observed using calculated torsions and deflections of an AFM cantilever. The lateral contractions are related to the calcium intensity within rather than the vertical beating power of the cardiomyocytes. Drug-induced nanomechanical changes of cardiomyocytes were further investigated by measuring lateral contractions in real time.

Citation

Yuansheng Liu, Jiantao Feng, Liang Shi, Ruibin Niu, Quanmei Sun, Hao Liu, Jing Li, Jihong Guo, Jihong Zhu, Dong Han. In situ mechanical analysis of cardiomyocytes at nano scales. Nanoscale. 2012 Jan 7;4(1):99-102