Quantitation of human herpesvirus-6 (HHV-6) DNA in a cord blood transplant recipient with chromosomal integration of HHV-6.

D Kobayashi, K Kogawa, K Imai, T Tanaka, S Hiroi, H Satoh, K Tanaka-Taya, S Nonoyama

Department of Pediatrics, Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit, Michigan 48201-2119, USA. dkobayas@dmc.org

Transplant infectious disease : an official journal of the Transplantation Society 2011 Dec

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Chromosomal integration of the human herpesvirus-6 (HHV-6) genome (CIHHV-6) is an important consideration if HHV-6 DNA is detected during the course of transplantation. A 4-year-old girl with refractory anemia with excess blasts type-2 was diagnosed with CIHHV-6 before a cord blood transplantation. HHV-6 DNA was serially quantitated by polymerase chain reaction assay in the transplant period. The possibility of HHV-6 reactivation in a transplant recipient with CIHHV-6 was suspected in our case. © 2011 John Wiley & Sons A/S.

Citation

D Kobayashi, K Kogawa, K Imai, T Tanaka, S Hiroi, H Satoh, K Tanaka-Taya, S Nonoyama. Quantitation of human herpesvirus-6 (HHV-6) DNA in a cord blood transplant recipient with chromosomal integration of HHV-6. Transplant infectious disease : an official journal of the Transplantation Society. 2011 Dec;13(6):650-3