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Bacillus subtilis induces expression of the gene ytnP in the presence of the antimicrobial streptomycin, produced by the Gram-positive bacterium Streptomyces griseus. ytnP encodes a lactonase-homologous protein that is able to inhibit the signaling pathway required for the streptomycin production and development of aerial mycelium in S. griseus.


Johannes Schneider, Ana Yepes, Juan C Garcia-Betancur, Isa Westedt, Benjamin Mielich, Daniel López. Streptomycin-induced expression in Bacillus subtilis of YtnP, a lactonase-homologous protein that inhibits development and streptomycin production in Streptomyces griseus. Applied and environmental microbiology. 2012 Jan;78(2):599-603

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PMID: 22101040

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