Inhibitory effect of asiatic acid on acetylcholinesterase, excitatory post synaptic potential and locomotor activity.

M N Nasir, J Abdullah, M Habsah, R I Ghani, G Rammes

Department of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia, Malaysia.

Phytomedicine : international journal of phytotherapy and phytopharmacology 2012 Feb 15

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The asiatic acid, a triterpenoids isolated from Centella asiatica was used to delineate its inhibitory effect on acetylcholinesterase (AChE) properties, excitatory post synaptic potential (EPSP) and locomotor activity. This study is consistent with asiatic acid having an effect on AChE, a selective GABA(B) receptor agonist and no sedative effect on locomotor. Copyright © 2011 Elsevier GmbH. All rights reserved.

Citation

M N Nasir, J Abdullah, M Habsah, R I Ghani, G Rammes. Inhibitory effect of asiatic acid on acetylcholinesterase, excitatory post synaptic potential and locomotor activity. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2012 Feb 15;19(3-4):311-6