Steroidal alkaloids from the bulbs of Fritillaria unibracteata.

Qing-Jian Zhang, Zhong-Fei Zheng, De-Quan Yu

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.

Journal of Asian natural products research 2011 Dec

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Two new steroidal alkaloids peimisine-3-O-β-D-glucopyranoside (1) and puqiedinone-3-O-β-D-glucopyranoside (3), together with three known compounds peimisine (2), puqiedinone (4), and puqiedine (5), were isolated and characterized from the bulbs of Fritillaria unibracteata. Their structures were fully elucidated by spectroscopic and chemical methods. Compound 1 showed moderate protection effect on neurotoxicity of PC12 cell lines induced by rotenone.

Citation

Qing-Jian Zhang, Zhong-Fei Zheng, De-Quan Yu. Steroidal alkaloids from the bulbs of Fritillaria unibracteata. Journal of Asian natural products research. 2011 Dec;13(12):1098-103