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As micronuclei (MN) derive from chromosomal fragments and whole chromosomes lagging behind in anaphase, the MN assay can be used to show both clastogenic and aneugenic effects. This particularly concerns the use of MN as a biomarker ofgenotoxic exposure and effects, where differences in MN frequencies between exposed subjects and referents are expected to be small. The present paper reviews the use of the MN assay in biomonitoring of occupational exposure studies.


L Palanikumar, N Panneerselvam. Micronuclei assay: A potential biomonitoring protocol in occupational exposure studies. Genetika. 2011 Sep;47(9):1169-74

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PMID: 22117400

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