Effects of exogenous carbon monoxide on radiation-induced bystander effect in zebrafish embryos in vivo.

V W Y Choi, M Y P Wong, S H Cheng, K N Yu

Department of Physics and Materials Science, City University of Hong Kong, Tat Chee Avenue, Kowloon Tong, Hong Kong.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 2012 Jul

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In the present work, the influence of a low concentration of exogenous carbon monoxide (CO) liberated from tricarbonylchloro(glycinato)ruthenium (II) (CORM-3) on the radiation induced bystander effect (RIBE) in vivo between embryos of the zebrafish was studied. RIBE was assessed through the number of apoptotic signals revealed on embryos at 25 h post fertilization (hpf). A significant attenuation of apoptosis on the bystander embryos induced by RIBE in a CO concentration dependent manner was observed. Copyright © 2011 Elsevier Ltd. All rights reserved.

Citation

V W Y Choi, M Y P Wong, S H Cheng, K N Yu. Effects of exogenous carbon monoxide on radiation-induced bystander effect in zebrafish embryos in vivo. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. 2012 Jul;70(7):1075-9