Ischemic stroke after recombinant factor VIIa treatment in acquired hemophilia A patient.

Abdullah Katgi, Pinar Ataca, Selda Kahraman, Ozden Pişkin, Mehmet A Ozcan, Fatih Demirkan, Güner H Ozsan, Bülent Undar

Department of Hematology, Dokuz Eylul University, Izmir, Turkey. drakatgi@gmail.com

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2012 Jan

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Acquired hemophilia is a rare, life-threatening coagulopathy in adults caused by the development of autoantibodies against factor VIII. Bypass agents such as recombinant factor VIIa (rFVIIa) are usually preferred for bleeding control; however, thromboembolic complications may occur. We report here a case that presented with extensive cutaneous and mucosal bleedings due to factor VIII inhibitors and was treated successfully with rFVIIa and steroid therapy, but was complicated with a life-threatening thromboembolic attack during follow-up.

Citation

Abdullah Katgi, Pinar Ataca, Selda Kahraman, Ozden Pişkin, Mehmet A Ozcan, Fatih Demirkan, Güner H Ozsan, Bülent Undar. Ischemic stroke after recombinant factor VIIa treatment in acquired hemophilia A patient. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis. 2012 Jan;23(1):69-70