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The aim of this work was the development of a feed-control for a succinic acid production fed-batch process. The performed batch trials indicated a correlation between succinic acid production and base consumption pH control. Based on the metabolism of Anaerobiospirillum succiniciproducens, a theoretical correlation between base consumption and glucose feed was established and proved in cultivation trials. With the established fed-batch process, the succinic acid yield could be increased to 0.875 (g/g glucose) in comparison to batch processes (0.60) with similar glucose concentrations. Additionally, the results indicate that the osmolarity of the medium has a significant influence on succinic acid production. Copyright © 2011 Wiley Periodicals, Inc.


Karlheinz Bretz, Stephan Kabasci. Feed-control development for succinic acid production with Anaerobiospirillum succiniciproducens. Biotechnology and bioengineering. 2012 May;109(5):1187-92

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PMID: 22125258

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