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Increases of pacing threshold stimulation are well documented with different antiarrhythmic drugs, but not with amiodarone. We report a case of a patient with dual-chamber pacing, with stable thresholds on repeated measurements on the last year, who presented severe increase of atrial pacing threshold resulting in loss of atrial capture after a year of treatment with amiodarone. Thresholds were normalized once amiodarone was removed. Ventricular thresholds were not affected. ©2011, The Authors. Journal compilation ©2011 Wiley Periodicals, Inc.


Juan Manuel Grande, Angel Grande, Maria Molina, Carolina Novo, Fernando Cabestrero. Atrial selective effect of amiodarone to increase threshold of excitation. Pacing and clinical electrophysiology : PACE. 2013 Mar;36(3):e93-6

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PMID: 22132864

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