Tristetraprolin down-regulates IL-17 through mRNA destabilization.

Hyun Hee Lee, Nal Ae Yoon, Mai-Tram Vo, Chae Won Kim, Je Moon Woo, Hee Jeong Cha, Young Woo Cho, Byung Ju Lee, Wha Ja Cho, Jeong Woo Park

Department of Biological Sciences, University of Ulsan, Ulsan 680-749, Republic of Korea.

FEBS letters 2012 Jan 2

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An excess of interleukin 17 (IL-17) may contribute to chronic inflammatory disorders, but mechanisms that regulate IL-17 in immune cells are unclear. Here we report that tristetraprolin (TTP) inhibits IL-17 production in human T cell lines. Overexpression of TTP decreased the expression of IL-17. Conversely, TTP inhibition by siRNA increased IL-17 production. IL-17 mRNA contains eight AREs within its 3'UTR. TTP bound directly to the IL-17 mRNA 3'UTR at a location between the fourth and seventh AREs and enhanced decay of IL-17 transcripts. These results suggest that TTP could control IL-17-mediated inflammation. Copyright © 2011. Published by Elsevier B.V.

Citation

Hyun Hee Lee, Nal Ae Yoon, Mai-Tram Vo, Chae Won Kim, Je Moon Woo, Hee Jeong Cha, Young Woo Cho, Byung Ju Lee, Wha Ja Cho, Jeong Woo Park. Tristetraprolin down-regulates IL-17 through mRNA destabilization. FEBS letters. 2012 Jan 2;586(1):41-6