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We report a clinical failure of a pneumococcal vaccine in a patient who developed pneumococcal pneumonia. In 2008, an 85-year-old Italian woman was admitted to the Respiratory Disease Unit of a hospital in Southern Italy. The 23-valent pneumococcal vaccine had been administered to the patient 50 days earlier. The chest x-ray disclosed a right basal bronchopneumonic focus. Streptococcus Pneumoniae serotype 19A, a strain included in the 23-valent pneumococcal vaccine, was isolated from the sputum. There is a need for more efficacious conjugated vaccines covering the majority of the pneumococcal serotypes that cause serious illness in older children and adults worldwide.


Silvio Tafuri, Domenico Martinelli, Anna Grimaldi, Annunziata Lopatriello, Vincenza Giorgio, Rosa Prato. 23-valent pneumococcal vaccine failure in a patient who developed pneumonia: a case report. The new microbiologica. 2011 Oct;34(4):417-20

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PMID: 22143817

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