Asymmetric synthesis of trans-2,3-disubstituted indoline derivatives.

Kyoung Hee Kang, Junghwan Do, Yong Sun Park

Department of Chemistry, Konkuk University, Seoul 143-701, Korea.

The Journal of organic chemistry 2012 Jan 6

filter terms:

A novel method for asymmetric synthesis of trans-2,3-disubstituted indolines has been developed. The strategy involves the (-)-sparteine-mediated electrophilic substitution of 2-benzyl N-pivaloylaniline with aromatic or α,β-unsaturated aldehydes and subsequent intramolecular nucleophilic substitution. The simple protocol for two-step process can produce highly enantioenriched indolines 3a-o up to 98:2 er.

Citation

Kyoung Hee Kang, Junghwan Do, Yong Sun Park. Asymmetric synthesis of trans-2,3-disubstituted indoline derivatives. The Journal of organic chemistry. 2012 Jan 6;77(1):808-12