Physicochemical properties and inhibition effect on iron deficiency anemia of a novel polysaccharide-iron complex (LPPC).

Zhong-Shan Zhang, Xiao-Mei Wang, Zhi-Ping Han, Li Yin, Ming-Xing Zhao, Shu-Chi Yu

Department of Chemistry, Huzhou Teachers College, Huzhou 313000, China. zhzs@hutc.zj.cn

Bioorganic & medicinal chemistry letters 2012 Jan 1

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Porphyran (P) was extracted from red algae Porphyra by boiling water. A novel polysaccharide-iron complex (LPPC) was prepared under the alkaline condition by adding a ferric chloride solution to the low molecular weight porphyran (LP) solution. Physicochemical properties and inhibition effect on iron deficiency anemia of this complex were studied. The content of iron(III) in the complex is 21.57% determined with iodometry. The results indicate that LPPC was product required. The complex can increase red blood cell count (RBC), hemoglobin (Hb), Serum iron (SI), spleen index, spleen mass and mass of mice with iron deficiency anemia (IDA). Although the structure and deeper mechanisms on hemolytic anemia of LPPC should be further studied, LPPC is hoped to be developed as a late-model iron supplement which has a synergism on anemia. Crown Copyright © 2011. Published by Elsevier Ltd. All rights reserved.

Citation

Zhong-Shan Zhang, Xiao-Mei Wang, Zhi-Ping Han, Li Yin, Ming-Xing Zhao, Shu-Chi Yu. Physicochemical properties and inhibition effect on iron deficiency anemia of a novel polysaccharide-iron complex (LPPC). Bioorganic & medicinal chemistry letters. 2012 Jan 1;22(1):489-92