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Successful mitosis depends on the stable, yet regulated attachment of chromosomes to spindle microtubules. The kinetochore, a large macromolecular structure assembled at sites of centromeric heterochromatin, is responsible for generating and regulating these essential attachments. Over the last several years, concerted experimental efforts have brought the structural view of the kinetochore-microtubule interface more clearly into focus. Here, we review important recent advancements and discuss several unresolved questions regarding how kinetochores dynamically bridge mitotic chromosomes to spindle microtubules. Copyright © 2011 Elsevier Ltd. All rights reserved.

Citation

Jennifer G DeLuca, Andrea Musacchio. Structural organization of the kinetochore-microtubule interface. Current opinion in cell biology. 2012 Feb;24(1):48-56

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PMID: 22154944

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