Omar M Jeroudi, Abdul-Rahman R Abdel-Karim, Tesfaldet T Michael, Christopher Lichtenwalter, James A de Lemos, Owen Obel, Tayo Addo, Michele Roesle, Donald Haagen, Bavana V Rangan, Deepa Raghunathan, Monica DaSilva, Bilal Saeed, Joseph K Bissett, Rajesh Sachdeva, Vassilios V Voudris, Panagiotis Karyofillis, Biswajit Kar, James Rossen, Panayotis Fasseas, Peter Berger, Subhash Banerjee, Emmanouil S Brilakis
Veteran Affairs North Texas Healthcare System, Dallas, TX, USA.
EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology 2011 DecTo compare the intravascular ultrasonography (IVUS) findings between saphenous vein grafts (SVG) treated with paclitaxel-eluting stents (PES) vs. bare metal stents (BMS) in the Stenting Of Saphenous Vein Grafts (SOS) trial. Of the 80 SOS trial patients, 38 had both baseline and follow-up IVUS examination and were included in this substudy: 17 patients received 28 BMS in 26 lesions and 21 patients received 30 PES in 28 lesions. Quantitative IVUS analysis was performed to determine the volume of in-stent neointimal hyperplasia (NIH) - defined as the difference between stent volume and lumen volume in the stented segments. Baseline characteristics were similar between patients who did and did not undergo baseline and follow-up IVUS. Patients receiving BMS and PES had similar stent and lumen volumes immediately after stenting. At 12-month follow-up, compared to BMS, PES-treated lesions had significantly less NIH volume (3.4 vs. 21.9 mm³, p<0.001) and neointima hyperplasia progression (1.6 vs. 17.1 mm³, p<0.001). No significant differences were seen in the 5 mm segment proximal and distal to the stent. Compared to BMS, use of PES in SVG lesions is associated with significantly lower NIH formation, which may help explain the improved clinical outcomes with PES in these lesions.
Omar M Jeroudi, Abdul-Rahman R Abdel-Karim, Tesfaldet T Michael, Christopher Lichtenwalter, James A de Lemos, Owen Obel, Tayo Addo, Michele Roesle, Donald Haagen, Bavana V Rangan, Deepa Raghunathan, Monica DaSilva, Bilal Saeed, Joseph K Bissett, Rajesh Sachdeva, Vassilios V Voudris, Panagiotis Karyofillis, Biswajit Kar, James Rossen, Panayotis Fasseas, Peter Berger, Subhash Banerjee, Emmanouil S Brilakis. Paclitaxel-eluting stents reduce neointimal hyperplasia compared to bare metal stents in saphenous vein grafts: intravascular ultrasonography analysis of the SOS (Stenting of Saphenous Vein Grafts) trial. EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology. 2011 Dec;7(8):948-54
PMID: 22157480
View Full Text