Control of central and peripheral tolerance to melanocyte differentiation antigens by GILT.

Jürgen C Becker, David Schrama

General Dermatology, Medical University of Graz, Graz, Austria. juergen.becker@medunigraz.at

The Journal of investigative dermatology 2012 Jan

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The strict control of the T-cell receptor repertoire is essential for prevention of autoimmune diseases. The repertoire of T cells is primarily formed in the thymus through positive and negative selection. The risk of an incomplete removal of autoreactive T cells necessitates additional means to maintain peripheral tolerance. There is increasing evidence that the interferon (IFN)-γ-inducible lysosomal thiol reductase (GILT) allows peripheral tolerance to a melanocyte differentiation antigen by induction of specific regulatory T cells.

Citation

Jürgen C Becker, David Schrama. Control of central and peripheral tolerance to melanocyte differentiation antigens by GILT. The Journal of investigative dermatology. 2012 Jan;132(1):15-7