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The advent of combination antiretroviral treatment has had a profound impact on CNS HIV infection and its clinical complications, but neurological impairment still occurs in patients on systemically effective combination therapy, and in some patients it may be important to consider antiretroviral drug entry and effects within the CNS. There are now data on the CNS exposure for most antiretroviral drugs. This review focuses on the CNS pharmacokinetics and pharmacodynamics of antiretroviral drugs in humans, and also discusses controversies in this field.


Aylin Yilmaz, Richard W Price, Magnus Gisslén. Antiretroviral drug treatment of CNS HIV-1 infection. The Journal of antimicrobial chemotherapy. 2012 Feb;67(2):299-311

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PMID: 22160207

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