Role of NYGGF4 in insulin resistance.

Xiaoling Chen, Zhiqing Huang, Daiwen Chen, Gang Jia, Xiangbing Mao, Xiuqun Wu

Institute of Animal Nutrition, Sichuan Agricultural University, Yaan, 625014, Sichuan, People's Republic of China. chenxlh@hotmail.com

Molecular biology reports 2012 May

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Insulin resistance is a clinical condition that is characterized by reducing glucose uptake in response to insulin. A major factor in the development of insulin resistance syndrome is obesity. NYGGF4 is a novel gene that is abundantly expressed in the adipose tissue of obese subjects. NYGGF4 induced the secretion of FFAs and TNF-α and caused mitochondrial dysfunction, which may cause insulin resistance. This review will summarize the effect of NYGGF4 on the adipogenesis, glucose uptake and mitochondrial dysfunction in vitro, and the possible mechanism and signal pathway of NYGGF4 for insulin resistance.

Citation

Xiaoling Chen, Zhiqing Huang, Daiwen Chen, Gang Jia, Xiangbing Mao, Xiuqun Wu. Role of NYGGF4 in insulin resistance. Molecular biology reports. 2012 May;39(5):5367-71