Multicomponent approaches to 8-carboxylnaphthyl-functionalized pyrazolo[3,4-b]pyridine derivatives.

Yan Hao, Xiao-Ping Xu, Tao Chen, Li-Li Zhao, Shun-Jun Ji

Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, China.

Organic & biomolecular chemistry 2012 Jan 28

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A simple and novel protocol for the efficient synthesis of a series of 8-carboxylnaphthyl functionalized pyrazolo[3,4-b]pyridine derivatives was developed through a one-pot, three-component reaction involving acenaphthylene-1,2-dione and 1H-pyrazol-5-amine in acetic acid medium. The reaction represents the first facile conversion of acenaphthenequinone to naphthoic acid via C-C bond cleavage without need for multi-step transformation.

Citation

Yan Hao, Xiao-Ping Xu, Tao Chen, Li-Li Zhao, Shun-Jun Ji. Multicomponent approaches to 8-carboxylnaphthyl-functionalized pyrazolo[3,4-b]pyridine derivatives. Organic & biomolecular chemistry. 2012 Jan 28;10(4):724-8