Detection of mobile-genetic-element variation between colonizing and infecting hospital-associated methicillin-resistant Staphylococcus aureus isolates.

Alex J McCarthy, Aodhan S Breathnach, Jodi A Lindsay

Centre for Infection, Division of Clinical Sciences, St George’s University of London, London, United Kingdom. jlindsay@sgul.ac.uk

Journal of clinical microbiology 2012 Mar

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Whole-genome analysis by 62-strain microarray showed variation in resistance and virulence genes on mobile genetic elements (MGEs) between 40 isolates of methicillin-resistant Staphylococcus aureus (MRSA) strain CC22-SCCmecIV but also showed (i) detection of two previously unrecognized MRSA transmission events and (ii) that 7/8 patients were infected with a variant of their own colonizing isolate.

Citation

Alex J McCarthy, Aodhan S Breathnach, Jodi A Lindsay. Detection of mobile-genetic-element variation between colonizing and infecting hospital-associated methicillin-resistant Staphylococcus aureus isolates. Journal of clinical microbiology. 2012 Mar;50(3):1073-5