Three-component reactions of isocyanides, dialkyl acetylenedicarboxylates, and trans-cinnamoyl chlorides for the synthesis of highly functionalized 2-vinyl furans.

Abbas Ali Esmaeili, Mahdieh Zangouei, Rahele Hosseinabadi, Ali Reza Fakhari

Chemistry Department, University of Birjand, Birjand, Iran. aa_esmaeili@yahoo.com

Molecular diversity 2012 Feb

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In this study, we present a convenient and efficient method for the synthesis of novel, highly substituted 2-vinyl furans using a three-component reaction. The zwitterions generated from the reaction of isocyanides and dialkyl acetylenedicarboxylates are reacted with trans-cinnamoyl chlorides to produce the desired products in good yields.

Citation

Abbas Ali Esmaeili, Mahdieh Zangouei, Rahele Hosseinabadi, Ali Reza Fakhari. Three-component reactions of isocyanides, dialkyl acetylenedicarboxylates, and trans-cinnamoyl chlorides for the synthesis of highly functionalized 2-vinyl furans. Molecular diversity. 2012 Feb;16(1):145-50