Antimycobacterial activities of 5-alkyl (or halo)-3'-substituted pyrimidine nucleoside analogs.

Naveen C Srivastav, Neeraj Shakya, Sudha Bhavanam, Amogh Agrawal, Chris Tse, Nancy Desroches, Dennis Y Kunimoto, Rakesh Kumar

Department of Laboratory Medicine and Pathology, 1-71 Medical Sciences Building, Edmonton, AB, Canada T6G 2H7.

Bioorganic & medicinal chemistry letters 2012 Jan 15

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Several 5-alkyl (or halo)-3'-azido (amino or halo) analogs of pyrimidine nucleosides have been synthesized and evaluated against Mycobacterium bovis, Mycobacterium tuberculosis and Mycobacterium avium. Among these compounds, 3'-azido-5-ethyl-2',3'-dideoxyuridine (3) was found to have significant antimycobacterial activities against M. bovis (MIC(50)=1μg/mL), M. tuberculosis (MIC(50)=10μg/mL) and M. avium (MIC(50)=10μg/mL). Copyright © 2011 Elsevier Ltd. All rights reserved.

Citation

Naveen C Srivastav, Neeraj Shakya, Sudha Bhavanam, Amogh Agrawal, Chris Tse, Nancy Desroches, Dennis Y Kunimoto, Rakesh Kumar. Antimycobacterial activities of 5-alkyl (or halo)-3'-substituted pyrimidine nucleoside analogs. Bioorganic & medicinal chemistry letters. 2012 Jan 15;22(2):1091-4