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The synthesis of a trifluoromethylphenyl diazirine photoaffinity probe of the cytohesin inhibitor SecinH3 is described. The probe exhibits improved labelling efficiency over a benzophenone-based probe and thus is more suitable for photoaffinity labelling in complex biological samples.

Citation

Barbara Albertoni, Jeffrey S Hannam, Damian Ackermann, Anton Schmitz, Michael Famulok. A trifluoromethylphenyl diazirine-based SecinH3 photoaffinity probe. Chemical communications (Cambridge, England). 2012 Jan 30;48(9):1272-4

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PMID: 22179571

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