Connexin43 regulates sodium current; ankyrin-G modulates gap junctions: the intercalated disc exchanger.

Mario Delmar

Cardiovascular research 2012 Feb 1

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Intercalated disc structures have conventionally been considered to be independent. Recent work shows that molecules initially thought of as belonging to one complex can actually affect another. Here, I focus on the cross-talk between connexin43 (Cx43, 'the gap junction protein') and the sodium channel complex and, conversely, on ankyrin-G (AnkG, a 'component of the sodium channel complex') and gap junctions. I speculate as to the possibility that one molecule affects the function of the other by regulating its trafficking into the intercalated disc.

Citation

Mario Delmar. Connexin43 regulates sodium current; ankyrin-G modulates gap junctions: the intercalated disc exchanger. Cardiovascular research. 2012 Feb 1;93(2):220-2