Toxic epidermal necrolysis with ocular involvement following vaccination for hemorrhagic fever with renal syndrome.

Young Hoon Hwang, Myung Seung Kang, Kyung O Lim, Sang Mok Lee

Department of Ophthalmology, Armed Forces Capital Hospital, Seongnam, Korea.

Yonsei medical journal 2012 Jan

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We report a case of toxic epidermal necrolysis with ocular involvement following vaccination for hemorrhagic fever with renal syndrome. A healthy 20-year-old male soldier presented with confluent purpuric and erythematous dusky red macules evolving to flaccid blister and epidermal detachment on the whole body with conjunctival injection. The patient had no antecedent medical or surgical conditions except for two doses of hemorrhagic fever with renal syndrome vaccination. With supportive care, skin lesions were improved. Ophthalmic examinations revealed conjunctival injection with epithelial defects in both eyes. Ocular complications were resolved after amniotic membrane transplantation. Toxic epidermal necrolysis may be considered as a possible complication of hemorrhagic fever with renal syndrome vaccination.

Citation

Young Hoon Hwang, Myung Seung Kang, Kyung O Lim, Sang Mok Lee. Toxic epidermal necrolysis with ocular involvement following vaccination for hemorrhagic fever with renal syndrome. Yonsei medical journal. 2012 Jan;53(1):228-30