Polystyrene nanoparticles affecting blood coagulation.

Cecilia Oslakovic, Tommy Cedervall, Sara Linse, Björn Dahlbäck

Division of Clinical Chemistry, Department of Laboratory Medicine, Lund University, Skåne University Hospital, Malmö, Sweden.

Nanomedicine : nanotechnology, biology, and medicine 2012 Aug

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The association of nanoparticles (NPs) with blood coagulation proteins may influence the natural balance between pro- and anticoagulant pathways. We investigated whether polystyrene NPs, when added to human plasma, affected the generation of thrombin in plasma. Amine-modified NPs were found to decrease the thrombin formation due to binding of factors VII and IX to the NPs, which resulted in depletion of the respective protein in solution. In contrast, carboxyl-modified NPs were able to act as a surface for activation of the intrinsic pathway of blood coagulation in plasma. These results highlight the influence of NPs on a biologically important pathway. Copyright © 2012 Elsevier Inc. All rights reserved.

Citation

Cecilia Oslakovic, Tommy Cedervall, Sara Linse, Björn Dahlbäck. Polystyrene nanoparticles affecting blood coagulation. Nanomedicine : nanotechnology, biology, and medicine. 2012 Aug;8(6):981-6