Advanced oxidation protein products and advanced glycation end products in children and adolescents with chronic renal insufficiency.

Katarína Sebeková, Kristína Klenovicsová, Juliana Ferenczová, Juraj Hedvig, L'udmila Podracká, August Heidland

Institute of Molecular BioMedicine, Comenius University, Bratislava, Slovakia. kata.sebekova@gmail.com

Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation 2012 Jan

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Advanced oxidation protein products (AOPPs) represent dityrosine-containing cross-linked protein modifications formed mainly via myeloperoxidase reaction, supposed to accelerate the uremia-associated atherogenesis and renal fibrosis. DESIGN, SUBJECTS, AND MAIN OUTCOME MEASURES: In a cross-sectional study, we investigated the accumulation of AOPPs and advanced glycation end product (AGE)-specific fluorescence corrected for albumin in children and adolescents with chronic renal failure (CRF, n = 42), end-stage renal disease (ESRD, n = 12), kidney transplanted patients (Tx, n = 16), and age-matched healthy controls (n = 38). AOPP levels were 2.4-fold higher in the CRF and ESRD patients, and 1.6-fold higher in the transplanted subjects when compared with the controls (P < .001). In comparison with healthy controls, AGE levels rose 2-fold in the CRF, 7-fold in the ESRD, and 5-fold in the kidney transplanted children and adolescents, (P < .001). Patients with cardiovascular affliction presented with higher AGE levels than those without diagnosed cardiovascular disease (P < .02). In patients with stabilized renal function, AOPP and AGE levels did not change significantly during 12 months. Pattern of accumulation of AOPP and AGE in children and adolescents with chronic renal disease differs. Accelerated rise in AOPP levels in some children and adolescents in predialysis stage of chronic renal insufficiency, inadequate to deterioration of renal function, might require further attention. Copyright © 2012 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.

Citation

Katarína Sebeková, Kristína Klenovicsová, Juliana Ferenczová, Juraj Hedvig, L'udmila Podracká, August Heidland. Advanced oxidation protein products and advanced glycation end products in children and adolescents with chronic renal insufficiency. Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation. 2012 Jan;22(1):143-8