BaseSpace
Import Your Data
Literature

FAQ

More FAQs

Back to top
Clear Search sequence regions
(e.g. EGFR, glucose metabolic process, Lung cancer, Prostate, Laryngoscope, Trichostatin A)
Bookmark Forward

An alternative synthetic route for an antidiabetic drug, rosiglitazone.

Dhanaji V Jawale, Umesh R Pratap, Ramrao A Mane

Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad 431004, Maharashtra, India.

Bioorganic & medicinal chemistry letters 2012 Jan 15


filter terms:
  • 2 4- thiazolidinedione (2)
  • 2 4- thiazolidinedione (1)
  • antidiabetic drug (4)
  • benzaldehyde (1)
  • drug design (1)
  • molecular structure (1)
  • pyridine (1)
  • rosiglitazone (4)
  • stereoisomerism (1)
    • Sizes of these terms reflect their relevance to your search.

    A convenient and scalable four-step novel route has been developed for the synthesis of rosiglitazone (8), an antidiabetic drug. This multistep route requires 4-fluoro benzaldehyde (4), 2,4-thiazolidinedione (6) and 2-chloro pyridine (1) as key reactants and gives overall better yield of rosiglitazone. In addition, some steps have been accelerated, which leads to an overall time saving of 10h. Copyright © 2011 Elsevier Ltd. All rights reserved.

    Citation

    Dhanaji V Jawale, Umesh R Pratap, Ramrao A Mane. An alternative synthetic route for an antidiabetic drug, rosiglitazone. Bioorganic & medicinal chemistry letters. 2012 Jan 15;22(2):924-8

    Expand section icon Mesh Tags

    Expand section icon Substances


    PMID: 22200596

    View Full Text
    • Copyright © 2025 Illumina Inc. All rights reserved.