An alternative synthetic route for an antidiabetic drug, rosiglitazone.
Dhanaji V Jawale, Umesh R Pratap, Ramrao A Mane
Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad 431004, Maharashtra, India.
Bioorganic & medicinal chemistry letters 2012 Jan 15A convenient and scalable four-step novel route has been developed for the synthesis of rosiglitazone (8), an antidiabetic drug. This multistep route requires 4-fluoro benzaldehyde (4), 2,4-thiazolidinedione (6) and 2-chloro pyridine (1) as key reactants and gives overall better yield of rosiglitazone. In addition, some steps have been accelerated, which leads to an overall time saving of 10h. Copyright © 2011 Elsevier Ltd. All rights reserved.
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Dhanaji V Jawale, Umesh R Pratap, Ramrao A Mane. An alternative synthetic route for an antidiabetic drug, rosiglitazone. Bioorganic & medicinal chemistry letters. 2012 Jan 15;22(2):924-8
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PMID: 22200596
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