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A convenient and scalable four-step novel route has been developed for the synthesis of rosiglitazone (8), an antidiabetic drug. This multistep route requires 4-fluoro benzaldehyde (4), 2,4-thiazolidinedione (6) and 2-chloro pyridine (1) as key reactants and gives overall better yield of rosiglitazone. In addition, some steps have been accelerated, which leads to an overall time saving of 10h. Copyright © 2011 Elsevier Ltd. All rights reserved.


Dhanaji V Jawale, Umesh R Pratap, Ramrao A Mane. An alternative synthetic route for an antidiabetic drug, rosiglitazone. Bioorganic & medicinal chemistry letters. 2012 Jan 15;22(2):924-8

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PMID: 22200596

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