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Dnmt3a silences hematopoietic stem cell self-renewal.
Jennifer J Trowbridge, Stuart H Orkin
Department of Pediatric Oncology, Dana-Farber Cancer Institute, Division of Hematology/Oncology, Children's Hospital Boston, Boston, Massachusetts, USA. trowbridge@bloodgroup.tch.harvard.edu
Nature genetics 2012 JanSizes of these terms reflect their relevance to your search.
DNA methylation is an epigenetic mark stably directing gene expression throughout development. A new study uncovers a role for the DNA methyltransferase Dnmt3a in silencing self-renewal genes in hematopoietic stem cells (HSCs) to permit efficient hematopoietic differentiation.
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Jennifer J Trowbridge, Stuart H Orkin. Dnmt3a silences hematopoietic stem cell self-renewal. Nature genetics. 2012 Jan;44(1):13-4
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PMID: 22200773
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