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The purpose of this article is to provide an overview on the regulation of transcription in cancer cells. We describe here standard mechanisms of transcription in eukaryotic cells, an influence of common promoter polymorphisms contributing to malignant progression and DNA methylation as significant aspect of gene regulation. We also described transcription factors mechanism of action, and how their alteration can result in cancer.

Citation

Elzbieta Trzyna, Marcin Duleba, Marta Faryna, Marcin Majka. Regulation of transcription in cancer. Frontiers in bioscience (Landmark edition). 2012;17:316-30

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PMID: 22201746

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