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In clinical trials, sometimes only a single drug concentration can be measured from a patient, because of the burden on the patient. From a single concentration, we cannot generally obtain point estimates of each pharmacokinetic parameter in a patient. In this article, we propose a method to estimate the clearance using a one-compartment model of a single-bolus intravenous injection from a single concentration at a sampling point between 1.5 and 2.5 half-lives. This method requires an assumed value for the volume of distribution but is robust to misspecification. This approach is illustrated by simulated concentration data and cadralazine concentration data.


Takashi Funatogawa, Ikuko Funatogawa. An estimation method of the clearance for a one-compartment model of a single bolus intravenous injection by a single sampling. Journal of biopharmaceutical statistics. 2012;22(1):43-53

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PMID: 22204526

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