Improved lycopene production by Blakeslea trispora with isopentenyl compounds and metabolic precursors.

State Key Laboratory of Chemical Resource Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, P.O. Box 75, 15 Beisanhuan East Road, Beijing, 100029, People's Republic of China.

Biotechnology letters 2012 May

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The highest lycopene production in mated cultures of Blakeslea trispora was 578 mg/l by adding 42 mg geraniol/l to the medium after 48 h of growth. The control gave 317 mg/l. Adding isopentenyl alcohol at 40 mg/l, mevalonic acid at 17.5 mg/l or dimethyl allyl alcohol at 150 mg, each after 36 h growth, gave lycopene yields 62, 45 and 47%, respectively, higher than the control.

Citation

Yan-qiu Shi, Xiu-lan Xin, Qi-peng Yuan. Improved lycopene production by Blakeslea trispora with isopentenyl compounds and metabolic precursors. Biotechnology letters. 2012 May;34(5):849-52