Analgesic and anti-inflammatory activity of β-sitosterol isolated from Nyctanthes arbortristis leaves.

Sunil A Nirmal, Subodh C Pal, Subhash C Mandal, Anuja N Patil

Department of Pharmacognosy, Pravara Rural College of Pharmacy, Pravaranagar, Maharashtra, India. nirmalsunil@rediffmail.com

Inflammopharmacology 2012 Aug

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Nyctanthes arbortristis Linn. (Oleaceae) is one of the well-known Indian medicinal plant. Various extracts of leaves of the plant were screened for analgesic activity by hot plate test and acetic acid-induced writhings and anti-inflammatory activity by carrageenan-induced hind paw edema method at the dose of 50 mg/kg, i.p. Petroleum ether extract was found to be most active and hence subjected to activity-guided fractionation. Results showed that β-sitosterol (5, 10 and 20 mg/kg, i.p.) was responsible for the significant and dose-dependent activity comparable with the standard extract. β-Sitosterol from N. arbortristis leaves might be responsible for analgesic and anti-inflammatory activity.

Citation

Sunil A Nirmal, Subodh C Pal, Subhash C Mandal, Anuja N Patil. Analgesic and anti-inflammatory activity of β-sitosterol isolated from Nyctanthes arbortristis leaves. Inflammopharmacology. 2012 Aug;20(4):219-24