Extended linkage disequilibrium in noncoding regions in a conifer, Cryptomeria japonica.

Etsuko Moritsuka, Yosuke Hisataka, Miho Tamura, Kentaro Uchiyama, Atsushi Watanabe, Yoshihiko Tsumura, Hidenori Tachida

Department of Biology, Kyushu University, Fukuoka 812-8581, Japan.

Genetics 2012 Mar

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We measured linkage disequilibrium in mostly noncoding regions of Cryptomeria japonica, a conifer belonging to Cupressaceae. Linkage disequilibrium was extensive and did not decay even at a distance of 100 kb. The average estimate of the population recombination rate per base pair was 1.55 × 10(-5) and was <1/70 of that in the coding regions. We discuss the impact of low recombination rates in a large part of the genome on association studies.

Citation

Etsuko Moritsuka, Yosuke Hisataka, Miho Tamura, Kentaro Uchiyama, Atsushi Watanabe, Yoshihiko Tsumura, Hidenori Tachida. Extended linkage disequilibrium in noncoding regions in a conifer, Cryptomeria japonica. Genetics. 2012 Mar;190(3):1145-8