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Metal ions stabilize quadruplex nucleic acids by coordinating the O6 guanine atoms from G-quartets. These quartets form the basic motif of quadruplex structures. This article systematically surveys the available crystallographic data on native quadruplexes, their ligand complexes and (in one instance) a protein complex. Three categories of quadruplex are examined, tetramolecular, bimolecular, and intramolecular: all are formed by telomeric nucleic acid sequences from human or ciliate organisms.

Citation

Nancy H Campbell, Stephen Neidle. G-quadruplexes and metal ions. Metal ions in life sciences. 2012;10:119-34

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PMID: 22210337

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