Nancy H Campbell, Stephen Neidle
The School of Pharmacy, University of London, London, WC1N 1AX, UK.
Metal ions in life sciences 2012Metal ions stabilize quadruplex nucleic acids by coordinating the O6 guanine atoms from G-quartets. These quartets form the basic motif of quadruplex structures. This article systematically surveys the available crystallographic data on native quadruplexes, their ligand complexes and (in one instance) a protein complex. Three categories of quadruplex are examined, tetramolecular, bimolecular, and intramolecular: all are formed by telomeric nucleic acid sequences from human or ciliate organisms.
Nancy H Campbell, Stephen Neidle. G-quadruplexes and metal ions. Metal ions in life sciences. 2012;10:119-34
PMID: 22210337
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