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Parenteral nutrition (PN) is a relatively recent life-saving development in medicine but brings with it a range of new potential complications. Much of our knowledge about the signs and symptoms of individual micronutrient deficiencies comes from observations of patients receiving PN, and an example of this is the pivotal paper by Velez and colleagues published in Journal of Parenteral and Enteral Nutrition in 1985. This case report was the first published study to identify acute thiamine deficiency with cardiopathy and metabolic acidosis occurring in adult patients receiving vitamin-free PN. Although the importance of thiamine has been recognized since the late 19th century, it is still unclear exactly what dose is required for full repletion of a deficient patient, and further research would be useful to elucidate this question.


Suzie Ferrie. Case report of acute thiamine deficiency occurring as a complication of vitamin-free parenteral nutrition. Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition. 2012 Feb;27(1):65-8

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PMID: 22227728

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