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The study of the definitive kidneys of 94 human embryos and fetuses at 4.5 to 12 weeks of gestation, has demonstrated that the formation of the proximal nephron tubules resulted from the cellular proliferation in the area of transition of the capsule of the renal corpuscle into the tubular part of the nephron that occurs only after the completion of the segregation of the renal corpuscle and the distal tubule within the nephron anlage. The formation of the renal tubules in the nephron anlage seems to be determined phylogenetically, while the initial differentiation of the distal tubule is a provisional feature.

Citation

S M Panteleev, L V Vikhareva, N G Mal'tseva, A L Ushakov, I Ia Khamoshina, O F Iaroslavtseva, R V Chivshina, N O Pal'chenkova, A V Margarian, M M Belkhoroeva. The assessment of the regularity of the nephron anlage tubule formation on the basis of provisionality principle]. Morfologii͡a (Saint Petersburg, Russia). 2011;140(5):13-7

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PMID: 22232988

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