Synthesis of lauryl grafted sodium alginate and optimization of the reaction conditions.

Jisheng Yang, Wen He

School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, China. jsyang@yzu.edu.cn

International journal of biological macromolecules 2012 Mar 1

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Lauryl grafted sodium alginate (SA-C(12)) was prepared by the reaction between sodium alginate and dodecanol with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) as a coupling agent. The structure of SA-C(12) was confirmed by FT-IR, (1)H NMR, and thermoanalysis. Meantime, the degree of substitution (DS) of SA-C(12) was determined by GC. The reaction conditions were studied systematically, which included reaction time and temperature, the molar ratio of hexuronic acid in alginate to dodecanol (N(hexuronic)/N(dodecanol)) and N(hexuronic)/N(EDC), the mass of toluenesulfonic acid. By investigating the relationship between these conditions and DS, the optimal conditions with the maximum DS were obtained. Copyright © 2011 Elsevier B.V. All rights reserved.

Citation

Jisheng Yang, Wen He. Synthesis of lauryl grafted sodium alginate and optimization of the reaction conditions. International journal of biological macromolecules. 2012 Mar 1;50(2):428-31