Serotonin syndrome associated with MDPV use: a case report.

Josh Mugele, Kristine A Nañagas, Laura M Tormoehlen

Indiana University School of Medicine, Indianapolis, IN, USA. jmugele@iupui.edu

Annals of emergency medicine 2012 Jul

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Serotonin syndrome is associated with use of certain street drugs, including methamphetamine, cocaine, and ecstasy. We describe a case of a woman who developed clinical findings consistent with serotonin syndrome after insufflation of 3,4-methylenedioxypyrovalerone (MDPV), a synthetic amphetamine. MDPV belongs to a group of substances called phenylethylamines, which are β-ketone analogs of other drugs of abuse, such as amphetamines and 3,4-methylenedioxymethamphetamine. She also received fentanyl initially during her hospitalization, which has also been associated with serotonin syndrome. In addition to benzodiazepines and supportive care, she was treated with cyproheptadine for 8 days, with slow resolution of her symptoms. Copyright © 2011. Published by Mosby, Inc.

Citation

Josh Mugele, Kristine A Nañagas, Laura M Tormoehlen. Serotonin syndrome associated with MDPV use: a case report. Annals of emergency medicine. 2012 Jul;60(1):100-2