Persistence of pneumolysin in the cerebrospinal fluid of patients with pneumococcal meningitis is associated with mortality.

Emma C Wall, Stephen B Gordon, Samia Hussain, Upali R S Goonetilleke, Jenna Gritzfeld, Matthew Scarborough, Aras Kadioglu

Clinical Research Group, Liverpool School of Tropical Medicine, United Kingdom.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2012 Mar 1

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Poor prognosis in Pneumococcal meningitis may be associated with high pneumolysin levels in cerebrospinal fluid (CSF). In patient samples we showed that pneumolysin levels in CSF remained high after 48 hours in nonsurvivors of meningitis compared with survivors. Selective antipneumolysin treatment may present a novel therapeutic option.

Citation

Emma C Wall, Stephen B Gordon, Samia Hussain, Upali R S Goonetilleke, Jenna Gritzfeld, Matthew Scarborough, Aras Kadioglu. Persistence of pneumolysin in the cerebrospinal fluid of patients with pneumococcal meningitis is associated with mortality. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2012 Mar 1;54(5):701-5